Recent Advances of Nanocrystals for Occular Fungal Keratits

Abstract

Scientists working on medication delivery formulations have a hurdle due to the eye's unique anatomy and makeup. The concern over the standard ocular formulation's lower bioavailability has sparked researchers' interest in creating other drug delivery systems. The bioavailability of medications can be improved by using formulations based on nanotechnology to get beyond the ocular barriers that exist in the eye. The development of numerous marketed medicines was facilitated by the introduction of nanocrystals, which helped address the issue of poorly soluble pharmaceuticals, particularly for oral and parenteral drug administration. Medication retention duration, bioavailability, and permeability across the corneal and conjunctival epithelium have all been demonstrated to increase with the use of nanocrystal-based formulations for ocular medication administration. We have emphasized the physiology of the eye and drug delivery hurdles in this review. The advantages and disadvantages of various ocular formulations based on nanotechnology are compared. Additionally, several techniques for creating nanocrystals using their unique technology are taken into account. This article emphasizes the usage of nanocrystals in overcoming a variety of ocular delivery problems while highlighting the benefits and applications for ocular formulation. We highlight the potential of using nanocrystals as a new approach to push the boundaries of ocular medication delivery.