Formulation and Evaluation of Amlodipine Cocrystals by Crystal Engineering Approach and Study of their Physicochemical Properties

Abstract

The Crystal Engineering is defined by G.R.Desiraju as “The understanding of intermolecular interactions in the context of crystal packing and utilization of such understanding in the design of new solids with desired physical and chemical properties. Cocrystal formation depends on functional groups present in drug molecule, physicochemical properties of co-former and solvent interactions. There are several methods to obtain cocrystals such as solvent evaporation, slurry crystallization, solid state grinding, melting, liquid assisted grinding. Novel strategies includes freeze drying, micro fluidic and ultrasound assisted cocrystallization. To overcome this problem several strategies have been developed to tune the properties of API’s such as salts, polymorphs, hydrates, solvates and cocrystals. However these approaches have certain limitations. But in case of cocrystals any API can form cocrystals with suitable conformer.