Design and Development of Ibuprofen Loaded Transferosomal Gel for Analgesic Activity

Abstract

Aim: The aim of this research study was to formulate transferosomes containing Ibuprofen as the topical gel for the treatment of analgesic activity.

Methods: Ibuprofen is a common nonsteroidal anti-inflammatory medication. It may be administered via transferosomes, which are ultra-deformable vesicles, due to their gastrointestinal disorders. Ibuprofen transferosomes were prepared by thin film hydration method. Transferosomes were assessed using different parameters like SEM, TEM, drug content, zeta potential, invitro drug release, and stability study.  Ibuprofen transferosomes were combined with Carbopol 934. The formulated transferosomal gel was evaluated for appearance, grittiness, pH, spreadability, extrudability, drug content, invitro drug release study and stability study.

Results: Nine transferosome formulations (F1-F9) are prepared with different ratios using a thin film hydration method. The formulated transferosomes are spherical in shape. The optimized formulation F2 containing 0.1 g Ibuprofen showed promising results having maximum drug release of 95.67% when compared to other formulations it has good stability property. Three formulations with different Carbopol 934 gel content (IG1-IG3) were prepared out of which IG3 was found to have maximum drug content 94.12% and also it showed maximum release of drug 96.78% from transferosome.

Conclusion: Ibuprofen-loaded transferosomal gel has the best analgesic effect. It is possible to conclude that transferosomes are a viable long-term delivery strategy for Ibuprofen as a topical gel with good stability.